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Transferrin-Saturation-Calculator

A Transferrin Saturation Calculator is an online tool that can help you know the Transferrin Saturation percentage. Learn More!

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Home / Health Insurance / Calculators / Articles / Transferrin Saturation Calculator

There are a lot of causes of low haemoglobin levels in the blood. One of the most common of these is Iron deficiency Anaemia, with a prevalence of up to 50% in some areas especially in women. Anaemia results in feeling weak and tired, high heart rate, dizziness, etc. Patients being evaluated for Anaemia are often asked to get Iron studies done. This includes checking for Iron and ferritin levels, total Iron binding capacity TIBC), and transferrin and transferrin saturation. Transferrin saturation is a simple measure to evaluate how effectively cells are able to perform their function of carrying oxygen.

What is a Transferrin Saturation Calculator?
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A Transferrin Saturation Calculator is an online tool that can help you know the Transferrin Saturation percentage by inputting the Serum Iron concentration and Total Iron-binding capacity. 

What is Transferrin Saturation?
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Transferrin is a protein produced by the liver that is responsible for transporting Iron. One transferrin particle can bind with two ions of Iron in its Ferric form. Transferrin binds to Iron particles in the intestine, where Iron is isolated from the food we consume. Once transferrin reaches places like the bone marrow where red blood cell production occurs, it encounters cells that have transferrin receptors. At this site, it releases the two Iron ions which are used to produce haemoglobin.

What is Total Iron Binding Capacity?
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Total Iron binding capacity (TIBC) is a medical term used to measure the amount of Iron that can be bound by transferrin, a protein responsible for transporting Iron in the blood. TIBC helps assess the body's ability to carry Iron, aiding in the diagnosis of conditions related to Iron deficiency or overload.

A high TIBC may suggest Iron deficiency Anaemia, where the body tries to increase its Iron-carrying capacity. It can also be seen in conditions like pregnancy or chronic inflammatory diseases. Conversely, a low TIBC may indicate Iron overload disorders like hemochromatosis or liver disease. Accurate interpretation requires considering TIBC in conjunction with other Iron-related parameters.

How to calculate Transferrin Saturation
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Transferrin saturation can be calculated using a calculator where: 

Transferrin saturation is a value that is obtained by the following formulae:

  1. Transferrin Saturation = {Serum Iron concentration ÷ Total Iron Binding Capacity (TIBC)} x 100 

  2. Transferrin Saturation = { Serum Iron concentration ÷ Serum Transferrin concentration} x 70.9

Who needs a transferrin saturation test?
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The blood is formed by many cells, one of which are red blood cells (RBCs) or erythrocytes. The main function of RBCs is to carry oxygen and nutrients to various parts of the body using a special protein called haemoglobin. 

For haemoglobin to be produced, Iron is essential. A fall in Iron levels can cause decreased haemoglobin production and, consequently a decrease in the RBCs. This clinical condition where there is a decrease in haemoglobin or in the number of RBCs is called Anaemia. 

There are many different types of Anaemia. One of the most common types of Anaemia is Iron Deficiency Anaemia, which as the name suggests, is due to low levels of Iron in the body. Symptoms of Iron Deficiency Anaemia include the following. 

Anaemia is diagnosed by blood tests. The first line of testing involves looking at blood cell counts and cell indices. If you are found to have a low level of haemoglobin, then further testing may be indicated by your doctor to determine the type of Anaemia. Transferrin Saturation is one of those tests.

Reference Range of Transferrin Saturation
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The normal Transferrin Saturation range is between 20-50%. This varies with gender & age. Typically the upper limit for men is usually 45-50%, and for women is 30-40%. 

When Transferrin Saturation is below 15% in females and 20% in males, it is diagnostic of Iron Deficiency Anaemia. When Transferrin Saturation is above 50%, it is considered as a condition of excess Iron in the body. 

This is summarised in the table below.

Gender

Reference range (in percentage %)

Male

20-50

Female

15-40

Interpretation of Transferrin Saturation Values
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Transferrin Saturation is a value that shows how many Iron binding sites on the transferrin molecules are actually bound with Iron particles. Therefore, when there is Iron deficiency, the Transferrin saturation is reduced as there is not enough Iron in the body to bind with the transferrin proteins. Hence, a low Transferrin Saturation is diagnostic of Iron Deficiency Anaemia. 

Conversely, a high Transferrin Saturation rate can indicate a state of Iron overload. This can occur in cases of:

Frequently Asked Questions (FAQs)
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Here’s a list of FAQs related to the Transferrin Saturation Calculator. Please consult a doctor for specific questions.

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I am a 24-year-old woman and my blood work shows my Transferrin Saturation is 13.2%. What does this mean? 

Transferrin Saturation is a value that is used to determine the status of Iron concentration in your body. The reference range for women is between 15-40%. Your Transferrin Saturation at 13.2% is below the lower limit and is hence indicative of Iron deficiency. Consult your doctor to determine what could be the cause of your Iron deficiency and how to rectify it. 

What is the treatment for Iron deficiency Anaemia?

Iron deficiency Anaemia is treated in different ways depending on the severity and patient factors. Iron can be given orally in the form of tablets or as intramuscular injections. Further treatment depends upon the cause of Anaemia.

Disclaimer: The content on this page is generic and shared only for informational and explanatory purposes. Please consult a doctor before making any health-related decisions.